Structural flexibility and functional interaction of mediator Cdk8 module
نویسندگان
چکیده
منابع مشابه
Distinct roles for Mediator Cdk8 module subunits in Drosophila development.
Mediator (MED) is a conserved multisubunit complex bridging transcriptional activators and repressors to the general RNA polymerase II initiation machinery. In yeast, MED is organized in three core modules and a separable 'Cdk8 module' consisting of the cyclin-dependent kinase Cdk8, its partner CycC, Med12 and Med13. This regulatory module, specifically required for cellular adaptation to envir...
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Mediator is a general coactivator of RNA polymerase II (Pol II) transcription. Genomic location analyses of different Mediator subunits indicate a uniformly composed core complex upstream of active genes but unexpectedly also upstream of inactive genes and on the coding regions of some highly active genes. The repressive Cdk8 submodule is associated with core Mediator at all sites but with a lo...
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Diese Dissertation wurde selbständig und ohne unerlaubte Hilfe erarbeitet. Acknowledgements I want to thank Patrick Cramer for everything that I learned during my PhD in his lab, especially for giving me the opportunity to work as independent as possible. are the four fellows who shared this whole time with me, I´m very glad that I met them and grateful for their understanding friendship. Sonja...
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ژورنال
عنوان ژورنال: Protein & Cell
سال: 2013
ISSN: 1674-800X,1674-8018
DOI: 10.1007/s13238-013-3069-y